Figure 8
From: PITX2 gain-of-function induced defects in mouse forelimb development
At E13.5 PITX2 and Six2 are co-expressed in a limited numbers of non-myogenic cells. (A and B) H&E stained sagittal sections of E13.5 wild type and Ktcn-PITX2 forelimbs. (C-H) At E13.5 both Pitx2 and Six2 are expressed in the developing forelimb musculature (*). (D, F) In the Ktcn-PITX2 forelimb, Six2 is also expressed in a limited numbers of the non-myogenic cells over-expressing PITX2 (arrow). Scale bar: 1 mm.