Figure 7
From: PITX2 gain-of-function induced defects in mouse forelimb development
Forelimbs of adult Ktcn-PITX2 mice display tendon anomalies. (A and B) The adult Ktcn-PITX2 limb musculature is twisted 180 degrees compared to wild type. Still, all muscle groups are present. (C) Normally, biceps brachii inserts at the proximal part of the radius (white arrow). (D) In the Ktcn-PITX2 mice biceps brachii insertion is altered (white arrow) as its distal end is curled around the radius (black arrow) and inserts dorsally at the very most distal part of the bone.