Figure 2
From: PITX2 gain-of-function induced defects in mouse forelimb development
Skeletal malformations are present in E18.5 and in newborn Ktcn-PITX2 mice. Alizarin Red and Alcian Blue stainings of forelimbs from E18.5 (upper section) and newborn (lower section) mice. Forelimbs of E18.5 and newborn Ktcn-PITX2 mice display a diminished deltoid tuberosity (*). Newborn Ktcn-PITX2 mice also exhibit a thickening of the distal humerus, which tends to partly dislocate the radius anteriorly and also slightly dislocate the proximal part of the ulna in a more lateral-dorsal position, which makes the ulna appear twisted (arrows).