Figure 1
From: PITX2 gain-of-function induced defects in mouse forelimb development
Forelimbs of Ktcn-PITX2 mice exhibit severe bone malformations. (A) X-ray images and Alizarin Red staining of wild type (left panel) and Ktcn-PITX2 (right panel) adult forelimbs. Right panel: Alizarin Red staining of Ktcn-PITX2 forelimb (ventral view) shows a diminished and misplaced deltoid tuberosity. The humerus and radius are malformed. Note the proximal bend of the radius, which results in a posterior misplacement. (B) A Ktcn-PITX2 mouse displays the characteristic forelimb phenotype. Abbreviations: dt, deltoid tuberosity; h, humerus; r, radius; u, ulna.