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Figure 2 | BMC Developmental Biology

Figure 2

From: FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia

Figure 2

PDX1 expression. A-B: PDX1 immunostaining on E12.5 wildtype embryos. A: Strong PDX1 expression in pancreas. B: Much weaker, but still detectable nuclear PDX1 expression in the lung bud. A': Magnification from A. B': Magnification from B. C-H: PDX1 immunostaining on E18.5 TG and WT lung. C: PDX1 and E-cadherin IHC demonstrates that PDX1 is upregulated in the TG lung. D: FGF10 IHC on TG lung. E: Merge of PDX1 and FGF10 IHC demonstrates that not all PDX1 positive cells express cytoplasmic FGF10 (arrow), but all FGF10 producing cells express PDX1(arrowhead). F: PDX1 and E-cadherin IHC on WT lung. G: FGF10 IHC on WT lung. H: merge of F and G.

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BMC Developmental Biology

ISSN: 1471-213X

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