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Figure 7 | BMC Developmental Biology

Figure 7

From: Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse

Figure 7

Loss of de novo cholesterol synthesis does not perturb PGC migration. E12.5 gonads from (A) a Dhcr7+/- embryo and (B) a Dhcr7-/- littermate. Gonads were stained for the PGC marker SSEA1. Similar results were seen for four Dhcr7-/- embryos derived from two litters. E12.5 gonads dissected from (C) an Sc5d +/- embryo and (D) an Sc5d-/- littermate. Similar results were seen for seven Sc5d-/- embryos derived from four litters. Scale bar is 146 μm.

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