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Figure 1 | BMC Developmental Biology

Figure 1

From: The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila

Figure 1

Structure of Dlk and the 3 isoforms. A) Schematic representation of several members of the Delta-Serrate family of Notch ligands. Comparative structure is shown including the EGF-repeats, signal peptide, extracellular proteolytic cleavage domain and transmembrane domain found in all the ligands in addition to the DSL domain that is missing in mouse DLK1. B) Schematic representation of the three DLK1 isoforms expressed in Drosophila. The M construct produces the membrane-bound isoform of DLK1, which lacks a proteolytic cleavage site. The SM construct produces the full-length DLK1 containing the proteolytic cleavage domain and the S form is engineered to produce the isoform normally generated by proteolytic cleavage.

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BMC Developmental Biology

ISSN: 1471-213X

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