Figure 5
Promoter and transcription factor binding site predictions at sox10 5' genomic sequences. Genomic sequences from multiple species were used to predict promoter regions (A) and transcription factor binding sites (B) at sox10 intron 1. (A) The position and size of intron 1 is indicated for each species. In each case, the promoter predicted by FirstEF is indicated in blue, with the corresponding predicted probability shown on the right. (B) The 3'-most region of sox10 intron 1 is shown for mammals, chicken and zebrafish. Highly conserved sequences among mammals were submitted to the TRANSFAC database, as was the entire sequence of intron 1 for chicken and zebrafish. Predictions common to all three are indicated in red (NFKappaB), yellow (Tcf/Lef), green (FoxD3) and blue (Sox family). Note that the prediction and organization relative to the start codon (ATG) of each are conserved between mammals, chicken and zebrafish.