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Figure 5 | BMC Developmental Biology

Figure 5

From: Bunched, the Drosophilahomolog of the mammalian tumor suppressor TSC-22, promotes cellular growth

Figure 5

bunB and bunC can interfere with bunA function. (A-H) Side view of wings overexpressing the indicated UAS transgenes under the control of the apterous-Gal4 (ap-Gal4) driver line. (A) EP-mediated expression of bunA does not produce a wing bending phenotype. (B) Overexpression of dS6K in the dorsal wing compartment leads to wing bending (eGFP was co-expressed as a control). The dS6K bent-down wing phenotype is enhanced when the EP-insertion GE12327 (C) or a UAS-bunA transgene (D) is used to co-overexpress bunA. Expression of bunA from the EP consistently results in stronger phenotypes than from the UAS-bunA transgene. (E) Co-overexpression of bunB leads to a complete suppression of the dS6K bent-down wing phenotype. (F) Expression of bunC suppresses the dS6K bent-down wing phenotype, and the suppression is even stronger when a copy of bunA is removed (G), indicative of a dominant negative effect of bunC on bunA. Consistently, co-expression of bunA interferes with the suppressing effect of bunC (H).

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