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Table 2 Tissue restricted expression of the genes isolated by whole mount in situ hybridization.

From: A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE)

Gene symbol Gene name L F E H T Expression pattern in E8.0–8.5
Group1: Genes expressed in definitive endoderm only
*Pyy peptide YY 19 14 9 0 23 foregut
5730521E12Rik 5730521E12Rik 9 9 25 63 97 midgut
Group2: Genes expressed in both definitive and yolk sac endoderm
Cldn9 Claudin9 18 4 4 1 9 definitive endoderm and yolk sac
Habp2 Hyaluronic binding protein 2 25 0 2 4 6 definitive endoderm and yolk sac
Spp2 Secreted phosphoprotein2 16 1 7 2 10 definitive endoderm and yolk sac
Ttr Transthyretin 29 4 1 7 12 definitive endoderm and yolk sac
Group3: Genes expressed in definitive endoderm, yolk sac and other germ layers
Cpn1 Carboxypeptidase N, polypeptide1 28 2 5 6 13 definitive endoderm, neural tube and yolk sac
1700011H14Rik 1700011H14Rik 27 1 2 4 7 definitive endoderm(weak), neural tube and yolk sac
Mogat2 Monoacylglycerol O-acyltransferase2 36 2 11 6 19 yolk sac endoderm, definitive endoderm, anterior ectoderm, and somite
Spink3 Serine peptidase inhibitor, Kazal type3 38 44 109 57 210 yolk sac endoderm, ectoderm and definitive endoderm
Phlda2 Pleckstrin homology-like domain, family A, member2 26 7 10 5 22 yolk sac endoderm, lateral plate mesoderm and ventral definitive endoderm
Trap1a Tumor rejection antigen P1A 17 1 5 6 12 definitive endoderm, yolk sac and midbrain and tailbud
Group4: Genes not expressed in yolk sac and heart, but expressed in other germ layers
Gabpb1 GA repeat binding protein, beta1 27 3 1 2 6 entire definitive endoderm, head and tailbud ectoderm and mesoderm, but not expressed at heart and yolk sac
*Cdx1 Caudal type homeo box1 13 0 17 4 21 3 germ layers of the posterior embryo
*Trh Thyrotropin releasing hormone 18 4 9 0 13 definitive endoderm, brain, midline
*Cyp26a1 Cytochrome P450, family 26, subfamily a, polypeptide1 24 0 5 9 14 tailbud
*Tbx1 T-box1 14 4 1 0 5 foregut and mesoderm
*Otx2 Orthodenticle homolog2 27 8 2 0 10 brain, foregut
Arg1 Arginase 1, liver 15 4 0 4 8 3 germ layers of the trunk, but not expressed at head, heart, tail bud and yolk sac
Gm784 Gene model 784 37 6 1 5 12 3 germ layers, but not expressed at heart and yolk sac
A230098A12Rik A230098A12Rik 10 3 1 1 5 3 germ layers, but not expressed at heart and yolk sac
Usp22 Ubiquitin specific peptidase 38 2 3 3 8 3 germ layers, but not expressed at heart and yolk sac
Group5: Genes expressed in yolk sac endoderm only
Tdh L-threonine dehydrogenase 19 1 7 11 19 yolk sac endoderm
Lgals2 Lectin, galactose-binding, soluble 2 18 1 2 6 9 yolk sac endoderm
Cubn Cubilin (intrisic factor-cobalamin receptor) 23 1 16 17 23 yolk sac endoderm
Pla2g12b Phospholipase A2, group12B 16 2 2 1 5 yolk sac endoderm
Apoc2 ApolipoproteinC-2 17 3 13 7 23 yolk sac endoderm
  1. L: number of libraries which the 3' most tag sequence of each gene present in; F, E, H, T: raw counts of the 3' most tag sequences for each gene in foregut library (F), whole endoderm library (E), hindgut library (H) and in the three endoderm libraries (T) respectively. *: genes validated in the first list.