Figure 5From: Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte culturesThe canonical Wnt signaling inhibitor, Dkk1, rescues Wnt-induced hyperkeratosis. NIK cultures were incubated with or without soluble dkk1 for 30 days, and the mitotic index of the basal layer of the organotypic cultures was assayed (A). The same cultures were stained with H&E, and cut on the z-axis to evaluate their differentiation (B).Back to article page