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Figure 7 | BMC Developmental Biology

Figure 7

From: Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex

Figure 7

Proposed model for Hairy1-mediated transcriptional repression in the prospective somite and caudal region of somites. In the prospective somite and caudal region of already formed somites, where sap18, sin3a and hairy1 expression co-localize, a homo- or hetero-dimer containing Hairy1, bound to specific promoter regulatory sequences, may interact with Sap18 through the Hairy1 C-terminal domain and recruit the Sin3/HDAC complex to the transcriptional site, thus repressing target gene expression.

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