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Figure 2 | BMC Developmental Biology

Figure 2

From: KIT is required for hepatic function during mouse post-natal development

Figure 2

Blood and germ cells phenotypes in mice homozygous for the Sco1 , Sco5 and Sow3 alleles. (A) Specific parameters including Red Blood Cells (RBC), Hemoglobin (Hb), hematocrit (Hct), Mean Red Cell volume (MRCV), Mean Cell Haemoglobin Concentration (MCHC), Mean Cell Hemoglobin (MCH), Red Cell Distribution Width (RCDW), Platelet, Mean Platelet Volume (MPV) and White Blood Cells (WBC) were determined for homozygous males (Sco1/Sco1, n = 5; Sow3/Sow3, n = 11; Sco5/Sco5, n = 6; Whc1/Whc1, n = 6) and compared to wild-type (wt, n = 11) individuals. Results are expressed as mean ± sem. (B) Testis were sectioned and stained with Hematoxylin and Eosin showing a normal appearance and organization in the Sco1 and Sco5 mutants. On the contrary, the seminiferous tubules of Sow3 adult mutant individuals are lacunar with a complete absence of all the layers corresponding to the differentiation of spermatogonial stem cells. The β-galactosidase pattern of expression reveals that Kittm1Alf/Sow3 mutant mice showed no pattern of spermatogenesis compared to Kittm1Alf/+.

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