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Figure 2 | BMC Developmental Biology

Figure 2

From: pRb-mediated control of epithelial cell proliferation and Indian Hedgehog expression in mouse intestinal development

Figure 2

Disruption of pRb induces cell proliferation. The embryonic intestine sections (E17.5) derived from RB+/- (A, B) or RB-/- (C, D) mice were stained by IHC with proliferating cell marker Ki67. The number of proliferative cell in RB null intestine was highly increased. An enlargement of the portion in the left-hand micrograph (A, C) is shown in the right-hand (B, D) micrograph. BrdU positive cells in embryonic intestine sections derived from RB+/+ (E, H), RB+/- (F, I) and RB-/- (G, J) mice were stained with anti-BrdU antibody conjugated with Alexa Fluor 488 (E, F, G) or DAPI (H, I, J).

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