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Figure 4 | BMC Developmental Biology

Figure 4

From: BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo

Figure 4

MO BDNFatg injected into N-PLAP transgenic X. tropicalis embryos exhibit possible disruption in mandibular trigeminal axon targeting. (A) A transgenic X. laevis embryo (St. 29) expressing N-PLAP following alkaline phosphatase reaction demonstrates the neurospecific labeling of CNS axons. The mandibular trigeminal nerve can be observed to project to the cement gland where terminal arborisation occurs. (B) The detection of cranial nerves in a transgenic tadpole (St. 47). (C) An uninjected X. tropicalis transgenic embryo (WT) displaying normal trigeminal nerve projection. (D) A MOC injected transgenic embryo and (E) a MO NT3 injected embryo show normal trigeminal nerve projection. (F) A MO BDNFatg injected transgenic embryo shows that the trigeminal axons appeared thinner and possibly less fasciculated. Some of the axons did not extend to the posterior cement gland where they normally innervate.

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