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Table 3 Excess Cdkn1c does not affect sexual maturity.

From: Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7

 

Age at 1st plug (days)

Age at 1st litter (days)

 

WT males

5D3 male

WT female

5D3 female

 

43

39

54

58

 

38

37

56

69

 

39

38

58

57

 

37

38

56

55

 

46

 

56

56

 

37

 

55

57

Average (s.d.)

40 (3.69)

38 (0.82)

56 (1.33)

59 (5.16)

  1. There was no significance difference in time to first plug between transgenic males and wild type littermates (P = 0.33). Transgenic females had their litters slightly later than wild type females. Although this difference did not show up as significant (P = 0.22), there was a large variation in timing within the transgenic females from 56 to 69 days. Furthermore, two females in this study never became pregnant.