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Figure 2 | BMC Developmental Biology

Figure 2

From: Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure

Figure 2

The effects of taurine on LTP induction in P18–25 groups. (A) Representative traces were recorded of field excitatory postsynaptic potentials (fEPSPs) before (a) and 60 min after (b) HFS in Con, Con+Tau, Lead and Lead+PW-Tau slices. (B) LTP was induced by stimulation at 100 Hz for 1 sec. For the sake of clarity, points are plotted every 3 min here and in subsequent LTP figures. The amplitude in the Lead group was depressed compared with that of Con group (p < 0.01). There was no significant difference in LTP amplitude between Con and Con+Tau groups (p > 0.05). The LTP amplitude in Lead+PW-Tau group was 12.0% higher than that of Lead group (p < 0.01) but still lower than that of controls (p < 0.01). (C) Histogram showing mean ± SEM percentage of fEPSP slope in 40–60 min normalized to the baseline response after HFS in Con, Con+Tau, Lead and Lead+PW-Tau subjects (Con: 175.1 ± 7.6%, n = 9; Con+Tau: 181.1 ± 8.3%, n = 8; Lead: 122.6 ± 9.6%, n = 8; Lead +PW-Tau: 137.3 ± 5.3%, n = 9). *p < 0.01, versus Con group. **p < 0.01, versus Lead group and p<0.01, versus Con group. One-way ANOVA with the Bonferroni post hoc test were used for statistical analysis.

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BMC Developmental Biology

ISSN: 1471-213X

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