Figure 3
From: Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
Bmp-signaling is required for foxi1 and dlx3b expression during gastrulation. (A-C, F-H) Expression of foxi1 and dlx3b is strongly reduced in bmp7 mutants or embryos injected with Vox and Vent morpholinos (MOs) in comparison to wild-type embryos. (D, E, I, J) Overexpression of bmp2b by mRNA injections at the 1-cell stage leads to an expansion of both foxi1 and dlx3b expression domains at the expense of anterior neural plate. (A-D, F-I) Lateral views at the end of gastrulation with dorsal to the right and anterior upward; (E, J) dorsal views of embryos shown in D and I with anterior towards the top. Scale bar: 100 μm