Table 3 Selected Gene Ontology terms associated with genes differentially expressed in both the OCT4 and SOX2 knock-downs.
Over-represented GO terms associated only with down-regulated gene sets | ||
|---|---|---|
Biological Process | No. of genes | P value |
primary metabolism | 318 | 0.000 |
establishment and/or maintenance of chromatin architecture | 23 | 0.000 |
mitotic cell cycle | 14 | 0.024 |
steroid biosynthesis | 9 | 0.004 |
activation of MAPK activity | 5 | 0.026 |
Molecular Function | No. of genes | P value |
catalytic activity | 236 | 0.000 |
ATP binding | 59 | 0.020 |
aminoacyl-tRNA ligase activity | 9 | 0.000 |
GABA receptor activity | 3 | 0.200 |
Over-represented GO terms associated only with up-regulated gene sets | ||
Biological Process | No. of genes | P value |
intracellular signaling cascade | 113 | 0.000 |
cell adhesion | 92 | 0.000 |
apoptosis | 68 | 0.000 |
cell differentiation | 61 | 0.000 |
cytoskeleton organization and biogenesis | 46 | 0.000 |
skeletal development | 23 | 0.000 |
muscle development | 20 | 0.000 |
Wnt receptor signaling pathway | 16 | 0.002 |
cell cycle arrest | 13 | 0.001 |
blood vessel development | 11 | 0.013 |
Molecular Function | No. of genes | P value |
calcium ion binding | 94 | 0.000 |
transcription factor activity | 85 | 0.000 |
cytoskeletal protein binding | 63 | 0.000 |
protein kinase activity | 58 | 0.002 |
extracellular matrix structural constituent | 28 | 0.000 |