Figure 6
From: Wnt/β-catenin signaling is required for development of the exocrine pancreas
Pdx1 expressing progenitors are preserved in β-catenin KO pancreas. Panel A demonstrates immunofluorescent staining of E 12.5 pancreas from wildtype and β-catenin KO [CKO] revealing preservation of the Pdx1 expressing cell population. This suggests that the loss of exocrine pancreas seen later is not due to a loss of Pdx1 expressing progenitors. Panel B depicts E14.5 pancreas from wildtype and β-catenin KO stained for PTF1p48. Note the significant reduction in PTF1 expressing cells is already obvious at this developmental stage.