Table 1 Summary of ocular phenotypes
From: Rybp, a polycomb complex-associated protein, is required for mouse eye development
Ocular phenotype | Examined Mutant | No. with ocular phenotype/No. of examined mutants | Penetrance (%) |
|---|---|---|---|
Coloboma (by E18.5) | Rybp heterozygous (+/-) mice | 5/15 | 33 |
Coloboma, lens defects (By E14.5) | Chimeric mice Rybp-/- <-> | 6 exencephalic/19 | 32 |
| Â | Rybp+/+ | 3 non exencephalic/19 | 16 |
Cataract (by 3 month) | ROSA26-Rybp/EGFP; αA-crystallin/Cre Tg/+ mice | 44/75 | 59 |
Neovascularization (by 3 month) | ROSA26-Rybp/EGFP; β-Actin/Cre Tg/+ mice | 30/87 | 35 |
Neovascularization (by 3 month) | ROSA26-Rybp/EGFP; β-Actin/Cre Tg/Tg mice | 30/38 | 80 |
Coloboma, irregular retinal folds, anterior chamber defects (by P7) | ROSA26-Rybp/EGFP; β-Actin/Cre Tg/Tg mice | 11/38 | 29 |