Figure 7
From: Rybp, a polycomb complex-associated protein, is required for mouse eye development
Abnormal lens development in the lens-specific Rybp transgenic mice. (A-D) Histological appearance of wild type (A, C) and ROSA26-RYBP/EGFP; αA-crystallin/Cre transgenic (B, D) lenses at early postnatal (P2) development (A, B) and adulthood (3 month) (C, D). (A, C) Wild type eyes with normal morphology of the lens epithelium and fiber cells. (B, D) Transgenic eyes showing cortical inhomogeneity as a sign of developing cataract and impaired lens development (B). Lenses of adult transgenic mice (3 month) show progressed cataractous morphology (D). CA; cataract, L; lens, LE; lens epithelium, T; transitional zone, TG; transgenic, WT; wild type; P; postnatal. Magnification: A-B (×160); C-D (×250); E-F (×120)