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Figure 2 | BMC Developmental Biology

Figure 2

From: The lin-35/ Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegans

Figure 2

Mapping and cloning of the rr33 mutant. (A) SNP-SNIP mapping as well as three-factor mapping approaches were used to map rr33 to the center of linkage group I, close to dpy-5. This region contains several well-defined free-duplications of which hDp61 rescued the rr33 mutant (+) whereas hDp41 did not (-). C32F10.2(RNAi) phenocopies the rr33 mutant phenotype. (B) A schematic representation of the C32F10.2 lin-35/Rb gene with black boxes representing the predicted pocket binding domains and the gray box indicating the 3' UTR. The location and the precise nucleotide changes in rr33 and n745 allele are indicated by arrows.

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