Figure 5
From: Development of the mammalian liver and ventral pancreas is dependent on GATA4
Development of the ventral pancreas is curtailed in Gata6-/- embryos. Expression of PDX1 was identified in 24 somite (E9.5) Gata6+/- (A) and Gata6-/- embryos by immunohistochemistry staining of the ventral pancreas (brown stain, white arrowheads) in both Gata6+/- and Gata6-/- embryos, however there was considerably fewer PDX1 positive cells in the ventral pancreas (B; brown stain, white arrowhead). PDX1 positive cells were also detected in the presumptive dorsal pancreatic region of Gata6-/- embryos (B; brown stain, black arrowhead). Scale bar = 50 μM