Figure 2

Multiple sequence alignment of Nogo-A/Rtn4-A protein. The multiple sequence alignment compares Nogo-A protein from mouse, rat, human, chicken and xenopus (Rtn4.2-A1). Putative Nogo-A specific functional domains based on conserved regions (CR1-8) having ≥ 70% for 7 or more amino acids with a sequence identity/strong group conservation. Inhibitory domains NiRΔ2 and NiGΔ20 were previously identified [11]. Amino acid color code: Red-KR, Orange-G, Yellow-P, Green-NQST, Cyan-ACFILMVW, Blue-HY, Magenta-DE. "*" denotes conserved residue; ":", conservation of a 'strong' group; ".", conservation of a 'weaker' group as defined by ClustalX (see methods) [Genbank: AY494005 and AY843529].