TY - CHAP AU - Ragan, I. PY - 2006 DA - 2006// TI - The innovative medicines initiative: a proposal with implications for the 3R's BT - NC3Rs ID - Ragan2006 ER - TY - JOUR AU - Gomez-Lechon, M. J. AU - Donato, M. T. AU - Castell, J. V. AU - Jover, R. PY - 2003 DA - 2003// TI - Human hepatocytes as a tool for studying toxicity and drug metabolism JO - Curr Drug Metab VL - 4 UR - https://doi.org/10.2174/1389200033489424 DO - 10.2174/1389200033489424 ID - Gomez-Lechon2003 ER - TY - JOUR AU - Gomez-Lechon, M. J. AU - Donato, M. T. AU - Ponsoda, X. AU - Castell, J. V. PY - 2003 DA - 2003// TI - Human hepatic cell cultures: in vitro and in vivo drug metabolism JO - Altern Lab Anim VL - 31 ID - Gomez-Lechon2003 ER - TY - JOUR AU - Papeleu, P. AU - Vanhaecke, T. AU - Rogiers, V. PY - 2006 DA - 2006// TI - Histone deacetylase inhibition: A differentiation therapy for cultured primary hepatocytes? JO - Current Enzyme Inhibition VL - 2 UR - https://doi.org/10.2174/157340806775473517 DO - 10.2174/157340806775473517 ID - Papeleu2006 ER - TY - JOUR AU - Papeleu, P. AU - Loyer, P. AU - Vanhaecke, T. AU - Elaut, G. AU - Geerts, A. AU - Guguen-Guillouzo, C. AU - Rogiers, V. PY - 2003 DA - 2003// TI - Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes JO - J Hepatol VL - 39 UR - https://doi.org/10.1016/S0168-8278(03)00288-5 DO - 10.1016/S0168-8278(03)00288-5 ID - Papeleu2003 ER - TY - JOUR AU - Rogiers, V. AU - Vercruysse, A. PY - 1998 DA - 1998// TI - Hepatocyte cultures in drug metabolism and toxicological research and testing JO - Methods Mol Biol VL - 107 ID - Rogiers1998 ER - TY - JOUR AU - LeCluysse, E. L. AU - Bullock, P. L. AU - Parkinson, A. PY - 1995 DA - 1995// TI - Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes JO - Adv Drug Del Rev VL - 22 ID - LeCluysse1995 ER - TY - JOUR AU - Krause, D. S. AU - Theise, N. D. AU - Collector, M. I. AU - Henegariu, O. AU - Hwang, S. AU - Gardner, R. AU - Neutzel, S. AU - Sharkis, S. J. PY - 2001 DA - 2001// TI - Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell JO - Cell VL - 105 UR - https://doi.org/10.1016/S0092-8674(01)00328-2 DO - 10.1016/S0092-8674(01)00328-2 ID - Krause2001 ER - TY - JOUR AU - Huttmann, A. AU - Li, C. L. AU - Duhrsen, U. PY - 2003 DA - 2003// TI - Bone marrow-derived stem cells and plasticity JO - Ann Hematol VL - 82 UR - https://doi.org/10.1007/s00277-003-0713-2 DO - 10.1007/s00277-003-0713-2 ID - Huttmann2003 ER - TY - JOUR AU - Friedenstein, A. J. AU - Chailakhyan, R. K. AU - Gerasimov, U. V. PY - 1987 DA - 1987// TI - Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers JO - Cell Tissue Kinet VL - 20 ID - Friedenstein1987 ER - TY - JOUR AU - Friedenstein, A. J. AU - Gorskaja, J. F. AU - Kulagina, N. N. PY - 1976 DA - 1976// TI - Fibroblast precursors in normal and irradiated mouse hematopoietic organs JO - Ex Hematol VL - 4 ID - Friedenstein1976 ER - TY - JOUR AU - Schwartz, R. E. AU - Reyes, M. AU - Koodie, L. AU - Jiang, Y. AU - Blackstadt, M. AU - Lund, T. AU - Lenvik, T. AU - Johnson, S. AU - Hu, W. S. AU - Verfaillie, C. M. PY - 2002 DA - 2002// TI - Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells JO - J Clin Invest VL - 109 UR - https://doi.org/10.1172/JCI0215182 DO - 10.1172/JCI0215182 ID - Schwartz2002 ER - TY - CHAP AU - Papeleu, P. AU - Elaut, G. AU - Rogiers, V. AU - Vanhaecke, T. ED - Pandalai, S. G. PY - 2002 DA - 2002// TI - Cell cultures as in vitrotools for biotransformation studies BT - Recent Research Developments in Drug Metabolism and Disposition PB - Transworld Research Network CY - Kerala, India ID - Papeleu2002 ER - TY - JOUR AU - Papeleu, P. AU - Vanhaecke, T. AU - Elaut, G. AU - Vinken, M. AU - Henkens, T. AU - Snykers, S. AU - Rogiers, V. PY - 2005 DA - 2005// TI - Differential effects of histone deacetylase inhibitors in tumor and normal cells-what is the toxicological relevance? JO - Crit Rev Toxicol VL - 35 UR - https://doi.org/10.1080/10408440590935639 DO - 10.1080/10408440590935639 ID - Papeleu2005 ER - TY - JOUR AU - Vanhaecke, T. AU - Henkens, T. AU - Kass, G. E. AU - Rogiers, V. PY - 2004 DA - 2004// TI - Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures JO - Biochem Pharmacol VL - 68 UR - https://doi.org/10.1016/j.bcp.2004.05.022 DO - 10.1016/j.bcp.2004.05.022 ID - Vanhaecke2004 ER - TY - JOUR AU - Vanhaecke, T. AU - Papeleu, P. AU - Elaut, G. AU - Rogiers, V. PY - 2004 DA - 2004// TI - Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view JO - Curr Med Chem VL - 11 UR - https://doi.org/10.2174/0929867043365099 DO - 10.2174/0929867043365099 ID - Vanhaecke2004 ER - TY - JOUR AU - Herold, C. AU - Ganslmayer, M. AU - Ocker, M. AU - Hermann, M. AU - Geerts, A. AU - Hahn, E. G. AU - Schuppan, D. PY - 2002 DA - 2002// TI - The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells JO - J Hepatol VL - 36 UR - https://doi.org/10.1016/S0168-8278(01)00257-4 DO - 10.1016/S0168-8278(01)00257-4 ID - Herold2002 ER - TY - JOUR AU - Yamashita, Y. AU - Shimada, Y. AU - Harimoto, N. AU - Rikimura, T. AU - Shirabe, T. AU - Tanaka, S. AU - Sugimachi, K. PY - 2003 DA - 2003// TI - Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells JO - Int J Cancer VL - 103 UR - https://doi.org/10.1002/ijc.10699 DO - 10.1002/ijc.10699 ID - Yamashita2003 ER - TY - JOUR AU - Chiba, T. AU - Yokosuka, O. AU - Fukai, K. AU - Kojima, H. AU - Tada, M. AU - Arai, M. AU - Imazeki, F. AU - Saisho, H. PY - 2004 DA - 2004// TI - Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells JO - Oncology VL - 66 UR - https://doi.org/10.1159/000079503 DO - 10.1159/000079503 ID - Chiba2004 ER - TY - JOUR AU - Snykers, S. AU - Vanhaecke, T. AU - Papeleu, P. AU - Luttun, A. AU - Jiang, Y. AU - Vander Heyden, Y. AU - Verfaillie, C. AU - Rogiers, V. PY - 2006 DA - 2006// TI - Sequential Exposure to Cytokines Reflecting Embryogenesis: The Key for in vitro Differentiation of Adult Bone Marrow Stem Cells into Functional Hepatocyte-like Cells JO - Toxicol Sci VL - 94 UR - https://doi.org/10.1093/toxsci/kfl058 DO - 10.1093/toxsci/kfl058 ID - Snykers2006 ER - TY - JOUR AU - Shen, S. AU - Li, J. AU - Casaccia-Bonnefil, P. PY - 2005 DA - 2005// TI - Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain JO - J Cell Biol VL - 169 UR - https://doi.org/10.1083/jcb.200412101 DO - 10.1083/jcb.200412101 ID - Shen2005 ER - TY - JOUR AU - Gomez-Lechon, M. J. AU - Donato, M. T. AU - Castell, J. V. AU - Jover, R. PY - 2004 DA - 2004// TI - Human hepatocytes in primary culture: the choice to investigate drug metabolism in man JO - Curr Drug Metab VL - 5 UR - https://doi.org/10.2174/1389200043335414 DO - 10.2174/1389200043335414 ID - Gomez-Lechon2004 ER - TY - JOUR AU - Rogiers, V. AU - Vercruysse, A. PY - 1993 DA - 1993// TI - Rat hepatocyte cultures and co-cultures in biotransformation studies of xenobiotics JO - Toxicology VL - 82 UR - https://doi.org/10.1016/0300-483X(93)02611-J DO - 10.1016/0300-483X(93)02611-J ID - Rogiers1993 ER - TY - JOUR AU - Reyes, M. AU - Lund, T. AU - Lenvik, T. AU - Aguiar, D. AU - Koodie, L. AU - Verfaillie, C. M. PY - 2001 DA - 2001// TI - Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells JO - Blood VL - 98 UR - https://doi.org/10.1182/blood.V98.9.2615 DO - 10.1182/blood.V98.9.2615 ID - Reyes2001 ER - TY - JOUR AU - Jiang, Y. AU - Henderson, D. AU - Blackstad, M. AU - Chen, A. AU - Miller, R. F. AU - Verfaillie, C. M. PY - 2003 DA - 2003// TI - Neuroectodermal differentiation from mouse multipotent adult progenitor cells JO - PNAS VL - 100 UR - https://doi.org/10.1073/pnas.1834196100 DO - 10.1073/pnas.1834196100 ID - Jiang2003 ER - TY - JOUR AU - Henningson, C. T. AU - Stanislaus, M. A. AU - Gewirtz, A. M. PY - 2003 DA - 2003// TI - Embryonic and adult stem cell therapy JO - J Allergy Clin Immunol VL - 111 UR - https://doi.org/10.1067/mai.2003.133 DO - 10.1067/mai.2003.133 ID - Henningson2003 ER - TY - STD TI - Henkens T, Papeleu P, Elaut G, Vinken M, Rogiers V, Vanhaecke T: Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes. Toxicol Appl Pharmacol. ID - ref27 ER - TY - JOUR AU - Vinken, M. AU - Henkens, T. AU - Vanhaecke, T. AU - Papeleu, P. AU - Geerts, A. AU - Van Rossen, E. AU - Chipman, J. K. AU - Meda, P. AU - Rogiers, V. PY - 2006 DA - 2006// TI - Trichostatin A enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes JO - Toxicol Sci VL - 91 UR - https://doi.org/10.1093/toxsci/kfj152 DO - 10.1093/toxsci/kfj152 ID - Vinken2006 ER - TY - JOUR AU - Cascio, S. AU - Zaret, K. S. PY - 1991 DA - 1991// TI - Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation JO - Development VL - 113 ID - Cascio1991 ER - TY - JOUR AU - Shiojiri, N. PY - 1981 DA - 1981// TI - Enzymo- and immunocytochemical analyses of the differentiation of liver cells in the prenatal mouse JO - J Embryol Exp Morphol VL - 62 ID - Shiojiri1981 ER - TY - JOUR AU - Ott, M. O. AU - Rey-Campos, J. AU - Cereghini, S. AU - Yaniv, M. PY - 1991 DA - 1991// TI - vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression JO - Mech Dev VL - 36 UR - https://doi.org/10.1016/0925-4773(91)90071-D DO - 10.1016/0925-4773(91)90071-D ID - Ott1991 ER - TY - JOUR AU - Gao, B. AU - St Pierre, M. V. AU - Stieger, B. AU - Meier, P. J. PY - 2004 DA - 2004// TI - Differential expression of bile salt and organic anion transporters in developing rat liver JO - J Hepatol VL - 41 UR - https://doi.org/10.1016/j.jhep.2004.04.029 DO - 10.1016/j.jhep.2004.04.029 ID - Gao2004 ER - TY - JOUR AU - Seo, M. J. AU - Suh, S. Y. AU - Bae, Y. C. AU - Jung, J. S. PY - 2005 DA - 2005// TI - Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo JO - Biochem Biophys Res Commun VL - 328 UR - https://doi.org/10.1016/j.bbrc.2004.12.158 DO - 10.1016/j.bbrc.2004.12.158 ID - Seo2005 ER - TY - JOUR AU - Lee, K. D. AU - Kuo, T. K. AU - Whang-Peng, J. AU - Chung, Y. F. AU - Lin, C. T. AU - Chou, S. H. AU - Chen, J. R. AU - Chen, Y. P. AU - Lee, O. K. PY - 2004 DA - 2004// TI - In vitro hepatic differentiation of human mesenchymal stem cells JO - Hepatology VL - 40 UR - https://doi.org/10.1002/hep.20469 DO - 10.1002/hep.20469 ID - Lee2004 ER - TY - JOUR AU - Kang, X. Q. AU - Zang, W. J. AU - Song, T. S. AU - Xu, X. L. AU - Yu, X. J. AU - Li, D. L. AU - Meng, K. W. AU - Wu, S. L. AU - Zhao, Z. Y. PY - 2005 DA - 2005// TI - Rat bone marrow mesenchymal stem cells differentiate into hepatocytes in vitro JO - World J Gastroenterol VL - 11 UR - https://doi.org/10.3748/wjg.v11.i22.3479 DO - 10.3748/wjg.v11.i22.3479 ID - Kang2005 ER - TY - JOUR AU - Kang, X. Q. AU - Zang, W. J. AU - Bao, L. J. AU - Li, D. L. AU - Song, T. S. AU - Xu, X. L. AU - Yu, X. J. PY - 2005 DA - 2005// TI - Fibroblast growth factor-4 and hepatocyte growth factor induce differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocytes JO - World J Gastroenterol VL - 11 UR - https://doi.org/10.3748/wjg.v11.i47.7391 DO - 10.3748/wjg.v11.i47.7391 ID - Kang2005 ER - TY - JOUR AU - Hong, S. H. AU - Gang, E. J. AU - Jeong, J. A. AU - Ahn, C. AU - Hwang, S. H. AU - Yang, I. H. AU - Park, H. K. AU - Han, H. AU - Kim, H. PY - 2005 DA - 2005// TI - In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells JO - Biochem Biophys Res Commun VL - 330 UR - https://doi.org/10.1016/j.bbrc.2005.03.086 DO - 10.1016/j.bbrc.2005.03.086 ID - Hong2005 ER - TY - JOUR AU - Lange, C. AU - Bassler, P. AU - Lioznov, M. V. AU - Bruns, H. AU - Kluth, D. AU - Zander, A. R. AU - Fiegel, H. C. PY - 2005 DA - 2005// TI - Liver-specific gene expression in mesenchymal stem cells is induced by liver cells JO - World J Gastroenterol VL - 11 UR - https://doi.org/10.3748/wjg.v11.i29.4497 DO - 10.3748/wjg.v11.i29.4497 ID - Lange2005 ER - TY - CHAP AU - Aurich, I. AU - Mueller, L. P. AU - Aurich, H. AU - Luetzkendorf, J. AU - Tisljar, K. AU - Dollinger, M. AU - Schormann, W. AU - Walldorf, J. AU - Hengstler, J. AU - Fleig, W. E. AU - Christ, B. PY - 2006 DA - 2006// TI - Functional integration of human mesenchymal stem cell-derived hepatocytes into mouse livers BT - Gut ID - Aurich2006 ER - TY - JOUR AU - Li, W. AU - Liu, S. N. AU - Luo, D. D. AU - Zhao, L. AU - Zeng, L. L. AU - Zhang, S. L. AU - Li, S. PY - 2006 DA - 2006// TI - Differentiation of hepatocytoid cell induced from whole-bone-marrow method isolated rat myeloid mesenchymal stem cells JO - World J Gastroenterol VL - 12 ID - Li2006 ER - TY - JOUR AU - Ong, S. Y. AU - Dai, H. AU - Leong, K. W. PY - 2006 DA - 2006// TI - Inducing hepatic differentiation of human mesenchymal stem cells in pellet culture JO - Biomaterials VL - 27 UR - https://doi.org/10.1016/j.biomaterials.2006.03.022 DO - 10.1016/j.biomaterials.2006.03.022 ID - Ong2006 ER - TY - JOUR AU - Sarg, B. AU - Helliger, W. AU - Talasz, H. AU - Koutzamani, E. AU - Lindner, H. H. PY - 2004 DA - 2004// TI - Histone H4 hyperacetylation precludes histone H4 lysine 20 trimethylation JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M409099200 DO - 10.1074/jbc.M409099200 ID - Sarg2004 ER - TY - JOUR AU - D'Ippolito, G. AU - Schiller, P. C. AU - Ricordi, C. AU - Roos, B. A. AU - Howard, G. A. PY - 1999 DA - 1999// TI - Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow JO - J Bone Miner Res VL - 14 UR - https://doi.org/10.1359/jbmr.1999.14.7.1115 DO - 10.1359/jbmr.1999.14.7.1115 ID - D'Ippolito1999 ER - TY - JOUR AU - Koebe, H. G. AU - Wick, M. AU - Cramer, U. AU - Lange, V. AU - Schildberg, F. W. PY - 1994 DA - 1994// TI - Collagen gel immobilisation provides a suitable cell matrix for long term human hepatocyte cultures in hybrid reactors JO - Int J Artif Organs VL - 17 ID - Koebe1994 ER - TY - JOUR AU - Donato, M. T. AU - Gomez-Lechon, M. J. AU - Castell, J. V. PY - 1993 DA - 1993// TI - A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates JO - Anal Biochem VL - 213 UR - https://doi.org/10.1006/abio.1993.1381 DO - 10.1006/abio.1993.1381 ID - Donato1993 ER -