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Figure 4 | BMC Developmental Biology

Figure 4

From: An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model

Figure 4

A schematic diagram showing the boundaries of retained regions of HSA21 in transchromosomic teratomas, and their relationship to trisomic regions in mouse models of DS. The two regions labelled "INDI" were commonly retained by all tumours. As there were sufficient numbers of cells of many different tissue types in all tumours, and multiple HSA21 PCR markers were negative in the deleted regions, deletions must have occurred before any differentiation of ES cells in the tumours took place. The regions of the HSA21 gene map which are trisomic in some of the current segmental trisomy mouse models are indicated on the right by vertical lines, for comparison.

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