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Table 1 Top ranked 73 down-regulated genes in Ipf1/Pdx1-/- vs. Ipf1/Pdx1 +/+ e10.5 dorsal pancreatic buds

From: Gene array identification of Ipf1/Pdx1-/-regulated genes in pancreatic progenitor cells

Genbank acc. No.

Gene Symbol

Gene Name

Fold-change

Extracellular matrix proteins

   

NM_009263

Spp1

secreted phosphoprotein 1

-9.8 U *

NM_033525

Npnt

Nephronectin

-6.1 U

NM_145584

Spon1

spondin 1, (f-spondin) extracellular matrix protein

-3.8 K **

Transport

   

NM_172479

Slc38a5

solute carrier family 38, member 5

-8.8 U

NM_011401

Slc2a3

solute carrier family 2 (facilitated glucose transporter), member 3

-2.6 K

NM_009593

Abcg1

ATP-binding cassette, sub-family G (WHITE), member 1

-2.3 U

Signaling

   

NM_018763

Chst2

carbohydrate sulfotransferase 2

-4.5 U

XM_618828

Erbb3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

-3.2 U *

NM_019946

Mgst1

microsomal glutathione S-transferase 1

-3.2 K *

NM_152815

Lins2

Lines homolog 2 (Drosophila)

-2.4 U

NM_025505

Blzf1

basic leucine zipper nuclear factor

-2.0 K

Transcription factors

   

NM_013627

Pax6

paired box gene 6

-5.8 K *

NM_144955

Nkx6-1

Nkx transcription factor related, locus 1 (Drosophila)

-4.2 U ***

NM_008686

Nfe2l1

nuclear factor, erythroid derived 2,-like 1

-2.6 U

NM_010938

Nrf1

nuclear respiratory factor 1

-2.2 U

Cell adhesion

   

NM_008532

Tacstd1

tumor-associated calcium signal transducer 1

-3.2 U

NM_009864

Cdh1

cadherin 1

-2.6 U

Cell cycle

   

NM_013928

Schip1

schwannomin interacting protein 1

-3.1 K+U

NM_007631

Ccnd1

cyclin D1

-2.6 U

DNA binding

   

NM_198169

Gmeb2

glucocorticoid modulatory element binding protein 2

-2.9 U

NM_175074

Hmgn3

high mobility group nucleosomal binding domain 3

-2.4 K

Kinases/Phosphatases

   

NM_152804

Plk2

polo-like kinase 2 (Drosophila)

-2.9 K

NM_011950

Mapk13

mitogen activated protein kinase 13

-2.5 U

NM_008981

Ptprg

protein tyrosine phosphatase, receptor type, G

-2.4 U

Apoptosis

   

NM_008410

Itm2b

integral membrane protein 2B

-2.3 U

Other

   

NM_026433

1810057C19Rik

RIKEN cDNA 1810057C19 gene

-6.3 U

NM_153457

Rtn1

reticulon 1

-6.1 U *

NM_018737

Ctps2

cytidine 5'-triphosphate synthase 2

-5.9 U

NM_007694

Chgb

chromogranin B

-5.9 K

NM_026238

Narfl

nuclear prelamin A recognition factor-like

-4.9 U

NM_145562

9130213B05Rik

RIKEN cDNA 9130213B05 gene

-4.8 U

NM_011255

Rbp4

retinol binding protein 4, plasma

-4.2 U

NM_178747

Gulo

gulonolactone (L-) oxidase

-4.2 U

NM_025429

Serpinb1a

serine (or cysteine) proteinase inhibitor, clade B, member 1a

-4.2 U

AI451390

 

ESTs, transcribed locus

-4.0 U

NM_133977

Trf

Transferring

-4.0 K

NM_009412

Tpd52

tumor protein D52

-3.8 U

NM_016962

Spast

Spastin

-3.5 U

NM_015784

Postn

periostin, osteoblast specific factor

-3.3 U

NM_133697

1110003E01Rik

RIKEN cDNA 1110003E01 gene

-3.2 U

NM_145599

Tmem34

transmembrane protein 34

-3.1 U

NM_025633

Metapl1

methionine aminopeptidase-like 1

-3.0 U

XM_125538

Sesn1

Sestrin 1

-3.0 K

NM_013471

Anxa4

annexin A4

-3.0 K

NM_008188

Thumpd3

THUMP domain containing 3

-2.8 U

NM_026323

Wfdc2

WAP four-disulfide core domain 2

-2.7 U

NM_033073

Krt2-7

keratin complex 2, basic, gene 7

-2.7 U

BB529246

 

ESTs

-2.7 K

NM_178600

Vkorc1

vitamin K epoxide reductase complex, subunit 1

-2.6 U

NM_026524

Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

-2.6 K+U

NM_008792

Pcsk2

proprotein convertase subtilisin/kexin type 2

-2.6 K

NM_013778

Akr1c13

aldo-keto reductase family 1, member C13

-2.6 K

NM_011464

Spint2

serine protease inhibitor, Kunitz type 2

-2.5 U

NM_197996

Tspan15

tetraspanin 15

-2.5 U

NM_022316

Smoc1

SPARC related modular calcium binding 1

-2.5 U

NM_019972

Sort1

sortilin 1

-2.4 U

NM_176860

2810457I06Rik

RIKEN cDNA 2810457I06 gene

-2.4 U

XM_133714

4921517J23Rik

RIKEN cDNA 4921517J23 gene

-2.4 K

NM_146057

Dap

death-associated protein

-2.4 K

NM_013492

Clu

clusterin

-2.3 U

NM_198654

4833432M17Rik

RIKEN cDNA 4833432M17 gene

-2.3 U

NM_138651

Cds2

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2

-2.2 U

NM_145991

Hrpt2

hyperparathyroidism 2 homolog (human)

-2.2 U

NM_010485

Elavl1

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1

-2.2 U

AI451897

 

ESTs, transcribed locus

-2.2 U

NM_029341

Capsl

calyphosine-like

-2.2 K

NR_001592

H19

H19 fetal liver mRNA

-2.1 U

XM_110660

AI427122

expressed sequence AI427122

-2.1 U

NM_025853

1700022L09Rik

RIKEN cDNA 1700022L09 gene

-2.1 U

NM_138606

Pim2

proviral integration site 2

-2.1 K

NM_031170

Krt2-8

Keratin complex 2, basic, gene 8

-2.0 U

NM_025975

Tcte1l

t-complex-associated-testis-expressed 1-like

-2.0 K

NM_007657

Cd9

CD9 antigen

-2.0 K

  1. K = changes obtained from the 15 K microarray. U = changes obtained from the 21 K microarray. * = validated by qRT RT-PCR. ** = validated by qRT RT-PCR and in situ hybridization. *** = validated by qRT RT-PCR and immunohistochemistry.