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Figure 2 | BMC Developmental Biology

Figure 2

From: Characterization, developmental expression and evolutionary features of the huntingtin gene in the amphioxus Branchiostoma floridae

Figure 2

A. Sequence identity matrix of huntingtin, reconstructed from protein sequences: percent divergence is calculated by comparing sequence pairs in relation to their relative positions in the alignment; percent identity is estimated by comparing percent sequence identity directly without considering phylogenetic relationships. B. Unrooted tree of huntingtin proteins. (The huntingtin proteins used to reconstruct the tree were from the following species: H. sapiens,R. norvegicus, M. musculus, S. scrofa, G. gallus, X. tropicalis, F. rubripes, T. negroviridis, D. rerio, C. savignyi, C. intestinalis, B. floridae). Phylogenetic analysis reveals that B. floridae huntingtin branching just basal to vertebrate huntingtin protein, and that it groups very robustly with vertebrate orthologues. The branch length in the tree is proportional to the number of amino acid substitutions, and the scale bar indicates 0.1 amino acid substitution per position in the sequences. The numbers on each node indicate the percentage confidence values based on 100 replicate bootstrap resamplings of the alignment data.

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