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Figure 2 | BMC Developmental Biology

Figure 2

From: Dermal fibroblasts derived from fetal and postnatal humans exhibit distinct responses to insulin like growth factors

Figure 2

Collagen production in response to IGF-I. Radio-labelled proline uptake assay demonstrating modulation of protein synthesis by IGF-I. Panel A and B depict IGF-I elicited changes in collagen and non-collagen synthesis respectively, by FDF (n = 3, open squares) and MDF (n = 3, closed diamonds). All data is represented as cpm/105 cells (mean ± sem). Panel C illustrates changes in relative collagen synthesis between MDF and FDF in response to IGF-I; data represented as % (mean ± sem). * p = < 0.05. MDF cell strains demonstrated significantly higher collagen synthesis than untreated controls at 50 and 100 ng/ml of IGF-I (*p = 0.034 and 0.047 respectively); and significantly higher %RCS than untreated controls at 10, 50 and 100 ng/ml of IGF-I (*p = 0.047, 0.021 and 0.028 respectively). In contrast FDF cell strains showed no significant effect of IGF-I treatment on either collagen or protein synthesis over the entire titration range.

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