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Table 1 Effects of three Cdk inhibitors on early development of the X. laevis embryo

From: Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis

effect on:

Chk1/2

Wee1

Δ34Xic1

cleavage cycles

dose-dependent lengthening [28, 29]

modest lengthening

modest lengthening [9]

Cdk1 activity

inhibits via Tyr phosphorylation [28]

inhibits via Tyr phosphorylation [10]

no effect [38]

Cdk2 activity

inhibits via Tyr phosphorylation [29]

persists with Tyr phosphorylation

stoichiometric inhibitor [38]

degradation of cyclin E

delayed [28]

delayed

delayed [9]

degradation of Cdc25A

premature [22, 29, 32]

delayed

delayed

Cdk kinase:ppase activity at the MBT

increased kinase: decreased ppase [32, 40]

increased kinase: decreased ppase

unknown kinase: decreased ppase

effect on apoptosis

inhibits [4, 29]

activates

activates