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Figure 5 | BMC Developmental Biology

Figure 5

From: Neuregulin3 alters cell fate in the epidermis and mammary gland

Figure 5

Ectopic expression of Nrg3 in the epidermis causes defects in the external genitalia, vibrissae, and hair. (A) External genitalia of male non-transgenic littermate is indicated with an arrow. (B) Enlarged external genitalia of K14-Nrg3 transgenic male is indicated with an arrow. (C) Vibrissae of non-transgenic littermate are indicated with an arrow. Note normal fur growth. (D) Vibrissae of K14-Nrg3 transgenic mouse (indicated with an arrow) are sparse and wispy in comparison to non-transgenic littermate. In one K14-Nrg3 founder and most progeny from this line sparse fur appeared as the mice aged (usually from P100 onward). (E) Oil red O -stained section of skin from non-transgenic littermate at P7 showing normal distribution of hair follicles. (F) Oil red O -stained section of skin from K14-Nrg3 transgenic founder at P7 showing abnormally close juxtaposition of hair follicles which are indicated with arrows.

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