Figure 5From: Neuregulin3 alters cell fate in the epidermis and mammary glandEctopic expression of Nrg3 in the epidermis causes defects in the external genitalia, vibrissae, and hair. (A) External genitalia of male non-transgenic littermate is indicated with an arrow. (B) Enlarged external genitalia of K14-Nrg3 transgenic male is indicated with an arrow. (C) Vibrissae of non-transgenic littermate are indicated with an arrow. Note normal fur growth. (D) Vibrissae of K14-Nrg3 transgenic mouse (indicated with an arrow) are sparse and wispy in comparison to non-transgenic littermate. In one K14-Nrg3 founder and most progeny from this line sparse fur appeared as the mice aged (usually from P100 onward). (E) Oil red O -stained section of skin from non-transgenic littermate at P7 showing normal distribution of hair follicles. (F) Oil red O -stained section of skin from K14-Nrg3 transgenic founder at P7 showing abnormally close juxtaposition of hair follicles which are indicated with arrows.Back to article page