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Table 1 Changes in gene expression by BMP4, Noggin, and BSA-soaked beads at E9.5-E11.5

From: The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup

Protein

Stage

Gene

Gene expression altered

BMP4

E11.5 (bead in lens)

Tbx5

10/12 (+)

  

Tbx2

11/13 (+)

  

Tbx3

3/3 (+)

  

Vax2

4/4 (-)

 

E10.5 (bead in mes)

Tbx5

3/8 (+)

  

Tbx2

1/4 (+)

  

Tbx3

0/2

  

Vax2

0/2

 

E9.5 (bead in mes)

Tbx5

3/3 (+)

  

Tbx2

2/2 (+)

BSA

E11.5 (bead in lens)

Tbx5

0/5

  

Tbx2

0/6

  

Tbx3

0/1

  

Vax2

0/6

 

E10.5 (bead in mes)

Tbx5

0/3

  

Tbx2

0/2

 

E9.5 (bead in mes)

Tbx5

0/2

Noggin

E10.5 (bead in mes)

Tbx5

6/6 (-)

  

Tbx2

4/4 (-)

  

Tbx3

0/2

  

Vax2

0/3

  1. Mes, mesenchyme; Altered gene expression after culture with bead: + indicates induction; - indicates repression. Bead implantation was into nasal peri-ocular mesenchyme.