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Table 1 Changes in gene expression by BMP4, Noggin, and BSA-soaked beads at E9.5-E11.5

From: The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup

Protein Stage Gene Gene expression altered
BMP4 E11.5 (bead in lens) Tbx5 10/12 (+)
   Tbx2 11/13 (+)
   Tbx3 3/3 (+)
   Vax2 4/4 (-)
  E10.5 (bead in mes) Tbx5 3/8 (+)
   Tbx2 1/4 (+)
   Tbx3 0/2
   Vax2 0/2
  E9.5 (bead in mes) Tbx5 3/3 (+)
   Tbx2 2/2 (+)
BSA E11.5 (bead in lens) Tbx5 0/5
   Tbx2 0/6
   Tbx3 0/1
   Vax2 0/6
  E10.5 (bead in mes) Tbx5 0/3
   Tbx2 0/2
  E9.5 (bead in mes) Tbx5 0/2
Noggin E10.5 (bead in mes) Tbx5 6/6 (-)
   Tbx2 4/4 (-)
   Tbx3 0/2
   Vax2 0/3
  1. Mes, mesenchyme; Altered gene expression after culture with bead: + indicates induction; - indicates repression. Bead implantation was into nasal peri-ocular mesenchyme.