Figure 1

Pld gene and protein structure. A. The Pld genomic locus is shown (42A15), as well as the closely located bicoid-interacting protein 3 (bin3) region (black). The Pld transcript is represented as boxes with exon numbers inside. The coding region is indicated in gray. ESTs representative of different 5' UTR splice isoforms found in BDGP are shown (GH: adult head; RE: embryos 0–22 h; GM: ovaries; LP: larvae and early pupae). B. The Pld domain organization is shown in comparison with mammalian PLD1 and 2. C. Identical and highly similar amino acids in human PLD2 are highlighted in red. (*) indicates the position of the mutant amino acid in the Pld-H1095N allele.