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Figure 2 | BMC Developmental Biology

Figure 2

From: Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death

Figure 2

Reduction of the number of TrkA- and TrkC-expressing cell in Necdin mutant DRGs. (A-C) Transverse section of E13.5 embryos double-labelled with an anti-Necdin antibody and with the riboprobes of Trka (A) or Trkb (B) or Trkc (C) respectively. In situ hybridisation on sections of lumbar DRGs from E13.5 wild type (D-F) and Necdin mutant (G-I) embryos with the riboprobes Trka (D, G), Trkb (E, H) and Trkc (F, I). (J) Number of Trk-expressing neurons in lumbar DRGs at E13.5. Shown are the box-plots, describing the number of neurons per square millimetre for five ganglia from five embryos of each genotype (mutant or wild type). Significant loss of TrkA- and TrkC-subpopulations is observed. Statistical comparisons are made using the Mann-Whitney test; asterisks show differences that are statistically significant (*, p < 0.05). Scale bar: 100 μm (A-I).

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