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Figure 5 | BMC Developmental Biology

Figure 5

From: Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects

Figure 5

The truncal OFT fails to rotate in Alk5/Wnt1-Cre mutants. Left (A, C) and right (B, D) lateral images of ink-injected control (A-B) and mutant (C-D) embryos at E11.5 demonstrate the abnormally straight OFT in mutants lacking the typical conotruncal transition (black arrow in A vs. black arrowhead in C) seen in control. Red arrowhead (C) points to the abnormally shaped aortic sac. Red "s", aortic sac; t, truncus; c, conus.

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BMC Developmental Biology

ISSN: 1471-213X

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