Figure 5

Anterior segment abnormalities in Pax6^+/-; Gli3^+/- eyes. Abnormal contacts between cornea and iris (A-C), lens and cornea (E) and iris and lens (D) were observed in Pax6^+/-; Gli3^+/- eyes. (A-C) Iris hyperplasia and formation of cyst-like structures involving iris, retina and cornea were also observed (C). (D, E) Some lenses of Pax6^+/-; Gli3^+/- animals were highly dysgenic. Some Gli3^+/- animals had iris tissue attached to the lens (arrow in F). i, iris; cs, corneal stroma; L, lens; c, cyst. Scale bars = 100 μm.