Figure 3

Retinal morphology of wild-type (A), Gli3^+/- (B, E), Pax6^+/- (C) and Pax6^+/-;Gli3^+/- (D, F-H) animals. Although a majority of Gli3^+/- retinae exhibit normal lamination (B), mild focal dysplasia is seen (E). Pax6^+/-; Gli3^+/- retinal phenotypes include thinning of the retina (D) and dysplasia (F-H). gcl, ganglion cell layer; inl, inner nuclear layer; onl, outer nuclear layer; ipl, inner plexiform layer; opl, outer plexiform layer; r, rosette. Scale bars = 100 μm.