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Table 2 Adult lifespan of age-1(mg109) dauer arrest suppressors.

From: Activated AKT/PKB signaling in C. elegansuncouples temporally distinct outputs of DAF-2/insulin-like signaling

Genotype Adult Lifespan
  Mean SE (n) Log-Rank
Wildtype a 14.9 0.33 255 -
age-1(mg109) a, b 21 0.66 142 -
daf-16(mg242);age-1(mg109) a 9.0 0.11 225 <0.0001g
daf-16(mg255);age-1(mg109) a 9.8 0.11 283 <0.0001g
age-1(mg109);akt-1(mg247) a 25.5 0.42 205 <0.0001c, g
age-1(mg109);pdk-1(mg261) a 20.2 0.69 166 <0.6941d, g
age-1(mg109);mg227 a 30.5 0.38 279 <0.0001g
Wildtype; control RNAi f 22.9 0.49 53 -
Wildtype; daf-16 RNAi f 16.4 0.26 107 -
age-1(mg109);mg227; daf-16 RNAi f 18.7 0.27 97  
  1. a Lifespan assays performed at 25°C
  2. b These are homozygote progeny of age-1(mg109) homozygous hermaphrodites that have been maternally rescued for dauer arrest [27].
  3. c Although the akt-1(mg247) allele increased mean lifespan compared to age-1(mg109) control animals, the median lifespan and maximum lifespan was not significantly affected (age-1(mg109)a, b, 25 days median, 32 days maximum; age-1(mg109);akt-1(mg247)a, 24 days median, 33 days maximum, Figure 4)
  4. d Wilcoxan P value = 0.2370.
  5. f Lifespan assays performed at 20°C.
  6. g P vs age-1(mg109)a, b
  7. SE, Standard error.
  8. n indicates the number of animals scored in at least three independent trials.