|
Genotype
|
Adult Lifespan
|
|---|
| |
Mean
|
SE
|
(n)
|
Log-Rank
|
|---|
|
Wildtype a
|
14.9
|
0.33
|
255
|
-
|
|
age-1(mg109)
a, b
|
21
|
0.66
|
142
|
-
|
|
daf-16(mg242);age-1(mg109)
a
|
9.0
|
0.11
|
225
|
<0.0001g
|
|
daf-16(mg255);age-1(mg109)
a
|
9.8
|
0.11
|
283
|
<0.0001g
|
|
age-1(mg109);akt-1(mg247)
a
|
25.5
|
0.42
|
205
|
<0.0001c, g
|
|
age-1(mg109);pdk-1(mg261)
a
|
20.2
|
0.69
|
166
|
<0.6941d, g
|
|
age-1(mg109);mg227
a
|
30.5
|
0.38
|
279
|
<0.0001g
|
|
Wildtype; control RNAi f
|
22.9
|
0.49
|
53
|
-
|
|
Wildtype; daf-16 RNAi f
|
16.4
|
0.26
|
107
|
-
|
|
age-1(mg109);mg227; daf-16 RNAi f
|
18.7
|
0.27
|
97
| |
- a Lifespan assays performed at 25°C
- b These are homozygote progeny of age-1(mg109) homozygous hermaphrodites that have been maternally rescued for dauer arrest [27].
- c Although the akt-1(mg247) allele increased mean lifespan compared to age-1(mg109) control animals, the median lifespan and maximum lifespan was not significantly affected (age-1(mg109)a, b, 25 days median, 32 days maximum; age-1(mg109);akt-1(mg247)a, 24 days median, 33 days maximum, Figure 4)
- d Wilcoxan P value = 0.2370.
- f Lifespan assays performed at 20°C.
- g P vs age-1(mg109)a, b
- SE, Standard error.
- n indicates the number of animals scored in at least three independent trials.
