Suppression of altered FIRE response in age-1(mg109) animals. Distribution of intestinal esterase activity in (A) well-fed or (B) fasted age-1(+) young adult animals exhibited the fasting-induced redistribution (arrows) of esterase from the intestinal cytoplasm (A) to a nuclear pattern (B). (C) age-1(mg109) adults were resistant to the FIRE response. Altered FIRE response of age-1(mg109) animals was suppressed by (D) daf-16(mg242) and (E) daf-16(mg255) alleles, but not by (F) akt-1(mg247), (G) pdk-1(mg261) or (H) mg227 mutations. Scale bars, 50 μm.