Figure 4

Lifespan is differentially affected by age-1(mg109) dauer arrest suppressors. Adult lifespan of wildtype, age-1(mg109) and suppressor mutations in the age-1(mg109) background, as indicated. age-1(mg109) animals were maternally rescued (mg109/mg109) progeny of mg109/+ hermaphrodites. (A) Both daf-16 alleles, mg242 and mg255, suppressed age-1(mg109) adult longevity. The mg242 allele, which affects both daf-16 splice forms, had a slightly stronger effect on age-1(mg109) longevity than the daf-16a-specific mg255 allele (P < 0.001, mg242 vs.mg255). (B) The akt-1 (mg247) and the pdk-1 (mg261) alleles did not significantly affect age-1(mg109) adult longevity. The mg227 allele enhanced age-1(mg109) adult longevity. Adult lifespan data is shown in Table 2.