Table 2 Genes differentially expressed in T1 α(-/-) vs T1 α (+/+) lungs at term.
From: Alterations in gene expression in T1α null lung: a model of deficient alveolar sac development
Microarrays | |||||
|---|---|---|---|---|---|
Gene | Fold | p | Acc # | Function | Lung expression and References |
Transcription factors | |||||
Egr1 | -3.6 | 0.013 | M28845 | early response gene | (+) (E23, E24) |
Nr4A1/Nur77 | -2.4 | 0.050 | X16995 | modulation of RA signaling | (+) (E25, E26) |
FosB | -1.6 | 0.023 | X14897 | regulation of cell cycle | (+) (E27) |
Rb1 | -1.5 | 0.048 | AV338260 | negative regulation of cell cycle | (+) (E28) |
Signal transduction | |||||
MKP-1 | -1.6 | 0.042 | X61940 | MAPK phosphatase; cell cycle | (+) (E29) |
PKCα binding protein | 1.5 | 0.043 | AV056986 | kinase activity | n.d. |
Cell signaling | |||||
Cyr61 | -2.8 | 0.0009 | M32490 | cell adhesion; growth factor bp | (+) (E30) |
Ion channels/transport | |||||
Cation channel C6 | -2.0 | 0.030 | U49069 | Ca2+ transport | (+) (E33) |
ATPase, H+ transp. V1B2 | -1.6 | 0.011 | U13838 | Cl-, H+ transporter; ATPase | (+) (E34) |
Enzymes | |||||
Leucine aminopeptidase 3 | -1.6 | 0.049 | AI839225 | proteolysis and peptidolysis | n.d. |
Immune system | |||||
IFN activated gene 205 | -1.8 | 0.048 | M74123 | n.d. | |
Other | |||||
S100a9 | -1.9 | 0.035 | M83219 | calcium ion binding | (+) (E35) |
Tumor differentially expressed 2 | -1.5 | 0.025 | AI834772 | (+) UniGene Mm.29344 | |
Additional sex combs like 1 | 1.8 | 0.032 | AI852340 | regulation of transcription | n.d. |
Gas5 | 3.0 | 0.007 | AI849615 | negative control of cell growth | (+) (E36) |