Table 1 Genes differentially expressed in T1 α(-/-) vs T1 α(+/+) lungs at E18.5.
From: Alterations in gene expression in T1α null lung: a model of deficient alveolar sac development
Microarrays | |||||
|---|---|---|---|---|---|
Gene | Fold | p | Acc # | Function | Lung expression and References |
Transcription factors | |||||
Sp1 | -1.82 | 0.01 | X60136 | regulation of transcription | (+) (E1) |
Sox11 | -1.64 | 0.05 | AF009414 | regulation of transcription | (+) (E2) |
Signal transduction | |||||
Insulin-like growth factor I | -1.92 | 0.016 | X04480 | anti-apoptosis, organogenesis | (+) (E3, E4) |
Sp 17 | -1.82 | 0.008 | Z46299 | cAMP-dependent protein kinase regulator | (+) (E5, E6) |
PKC delta | 1.50 | 0.026 | X60304 | protein serine/threonine kinase activity | (+) (E7) |
Signal-induced proliferation assoc.1 | 1.72 | 0.011 | D11374 | regulation of cell cycle | (+) UniGene Mm.3072 |
G protein gamma 3 linked | 1.90 | 0.005 | AF069954 | RNA transport | (+) UniGene Mm.345134 |
Pip5k2c | 2.35 | 0.005 | AV303514 | (+) UniGeneMm.22682 | |
Cytoskeleton/ECM | |||||
big-h3 | -1.50 | 0.006 | L19932 | cell adhesion | (+) (E8) |
dynein, cytoplasmic | 1.58 | 0.007 | AF063229 | microtubule-based movement | (+) (E9) |
Ion channels/transport | |||||
Chloride channel regulator Icln | -1.86 | 0.03 | U72059 | chloride transport, regulation of cell volume | (+) (E10) |
Solute carrier family 31 | 1.50 | 0.002 | AI839005 | copper ion transporter | (+) Unigene Mm.248637 |
Enzymes | |||||
YME1-like | -2.33 | 0.008 | AF090430 | metalloendopeptidase activity | (+) Unigene Mm.23335 |
Holocytochrome c synthetase | -2.01 | 0.009 | NM_008222 | lyase | (+) MGI:106911 |
Cytochrome P450, 51 | -1.81 | 0.011 | AW122260 | ||
Splicing factor 3a1 | -1.69 | 0.044 | AW120546 | nuclear mRNA splicing, via spliceosome | (+) UniGene Mm.156914 |
Phosphodiesterase 7A | -1.62 | 0.0095 | U68171 | metal dependent phosphohydrolases | (+) (E11) |
Ring finger protein 13 | -1.62 | 0.008 | AF037205 | ubiquitin-protein ligase activity | (+) UniGene Mm.274360 |
Ptgs1 | -1.54 | 0.008 | M34141 | prostaglandin biosynthesis | (+) (E12) |
Paraoxonase 2 | 1.50 | 0.02 | L48514 | arylesterase activity | (+) (E13) |
Protease serine 3 | 1.53 | 0.034 | AE000665 | n.d. | |
Cytochrome P450 4v3 | 1.57 | 0.006 | BC026957 | (+) UniGene Mm.245297 | |
Branched chain aminotransferase 2 | 1.66 | 0.013 | AF031467 | amino acid biosynthesis | (+) UniGene Mm.24210 |
Neuropsin | 1.74 | 0.011 | D30785 | serine-type endopeptidase activity | (+) (E14) |
Catalase 1 | 1.80 | 0.016 | AV083603 | response to oxidative stress | (+) (E15) |
Thioether S-methyltransferase | 1.99 | 0.012 | M88694 | methyl transferase activity | (+) (E16) |
Immune system | |||||
Histocompatibility 2, D1 | 1.54 | 0.002 | M69069 | antigen presentation | (+) UniGene Mm.33263 |
Complement C1qa | 1.82 | 0.004 | X58861 | complement activation | (+) UniGene Mm.370 |
Complement C1q B chain | 1.82 | 0.023 | M22531 | complement activation | (+) UniGene Mm.2570 |
Ubiquitination/Degradation system | |||||
Proteasome (macropain) alpha 2 | -2.08 | 0.046 | X70303 | ubiquitin-dependent protein catabolism | (+) UniGene Mm.252255 |
Tetratricopeptide repeat gene | -1.75 | 0.029 | AJ002730 | (+) (E17) | |
Ube2v2 | -1.58 | 0.022 | NM_023585 | ubiquiting conjugating enzyme activity | (+) UniGene Mm.235407 |
Transcription/Translation/Protein synthesis | |||||
Eukaryotic translation initiation fac.2A | -2.15 | 0.017 | AW061243 | regulation of protein biosynthesis | (+) UniGene Mm.196220 |
FK506-binding protein (FKBP23) | -1.82 | 0.011 | AF040252 | peptidyl-prolyl isomerase | (+) (E18) |
Eukaryotic translation initiation fac.1A | -1.72 | 0.036 | AI132207 | translation factor activity | (+) UniGene Mm.262037 |
Cell Adhesion/Migration | |||||
Vascular cell adhesion molecule 1 | -1.52 | 0.032 | M84487 | cell-cell adhesion | (+) (E19) |
Apoptosis | |||||
Programmed cell death 4 | -1.54 | 0.014 | D86344 | isomerase | n.d. |
Cell-cell interaction | |||||
Sema4b | -1.69 | 0.047 | AA266467 | cell differentiation, development | n.d. |
Ephrin B2 | -1.64 | 0.011 | U30244 | development, neurogenesis, organogenesis | (+) (E21) |
Ephrin A3 | 1.50 | 0.006 | U92885 | cell atraction-repulsion | (+) UniGene Mm.331159 |
Other | |||||
Exportin1/CRM1 homolog | -2.00 | 0.009 | AW123788 | protein-nucleus export | (+) UniGene Mm.217547 |
NMDA receptor-regulated gene 1 | -1.92 | 0.021 | AW260482 | angiogenesis, cell differentiation | (+) UniGene Mm.275281 |
Smarca5 | -1.83 | 0.05 | AA794509 | chromatin remodeling | (+) (E22) |
NP220 | -1.81 | 0.008 | D83033 | RNA binding | (+) UniGene Mm.132392 |
Angiomotin | -1.78 | 0.042 | AI854771 | cell migration | (+) UniGene Mm.100068 |
IL13 receptor alpha 1 | -1.67 | 0.02 | AA608387 | cytokine receptor activity | (+) UniGene Mm.24208 |
Kidney cell derived transcript | -1.69 | 0.008 | U13371 | myoD family inhibitor domain containing | (+) UniGene Mm.1314 |
Single strand DNA binding protein | -1.69 | 0.016 | AA881160 | DNA replication | n.d. |
Rnpc2 | -1.61 | 0.018 | AA688834 | transcription co-activator | (+) UniGene Mm.153895 |
ZAP3 | -1.61 | 0.008 | AB033168 | differentiation | (+) UniGene Mm.153183 |
ADP-ribosylation-like factor 6 IP2 | -1.57 | 0.02 | AA763874 | GTP-binding protein | (+) UniGene Mm.175403 |
Phosphatidylinositol glycan, class A | -1.59 | 0.025 | D31863 | GPI-anchor byosynthesis | (+) UniGene Mm.3781 |
Quaking | -1.56 | 0.04 | U44940 | vasculogenesis, locomotory behavior | (+) UniGene Mm.262294 |
WSB-1 | -1.52 | 0.023 | AF033186 | signaling | (+) UniGene Mm.307022 |
Sorting nexin 17 | 1.51 | 0.037 | AW123761 | receptor mediated endocytosis | (+) UniGene Mm.6118 |
Disabled homolog 2 interacting protein | 1.60 | 0.03 | AI837497 | GTPase activating protein | (+) UniGene Mm.29629 |
Zinc finger protein 64 | 1.73 | 0.026 | U49046 | development, transcription | (+) UniGene Mm.2095 |
Ribosomal protein L22 | 1.77 | 0.004 | AI853960 | ribosome biogenesis | (+) UniGene Mm.259907 |