Expression patterns of plexins and neuropilins are consistent with cooperative and separate functions during neural development

Table 2 Conservation of different domains between Plexin superfamily members

Pairwise alignment of individual domains of chicken Plexin proteins indicate that the intracellular SP (sex-plexin) domain is highly conserved between the different family members, whereas the two extracellular domains, SEMA and PSI (plexin/semaphorin/integrin), show far less conservation. Interestingly the conservation between individual domains of chicken plexinB1 and B2 is only slightly higher than the homology between class A and class B plexins, suggesting that chicken plexinBs are evolutionary quite distinct. Numbers indicate percentage of identical/conserved amino acids.

ISSN: 1471-213X