Figure 8From: Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formationGreen fluorescent protein and megalin expression in yolk sac visceral endoderm of mutant embryos. The cubilin gene targeting strategy (see Fig. 1) created a GFP reporter for cubilin locus expression. Shown in Ais an H&E stained section of a homozygous 8.0 dpc embryo. Shown in Bis anti-GFP fluorescence of a serial section to the one shown in A. Note that cells within the blood islands are expressing the GFP reporter. Shown in Cis an anti-megalin stained 8.0 dpc mutant embryo. Embryos in panels A-B are oriented such that anterior is to the left and posterior is to the right. The embryo in C is oriented with anterior to the right and posterior to the left. VE, yolk sac visceral endoderm; BI, blood island; Am, amnion; Asterisk, points to the boundary of the VE and presumed EE.Back to article page