Figure 3

Cubilin deficient 8–8.5 dpc embryos display growth retardation with formation of some mesodermal structures, but not somites. Shown are wild-type (A), heterozygous (B) and homozygous 8–8.5 dpc embryos (C-E), derived from a heterozygous intercross mating. Embryos in A and B have been dissected to lie in a planar configuration where as embryos in C-D are intact. Shown in Fand Gare H&E stained sections of 8.5 dpc wild-type (F) and mutant (G) embryos. Mutant 8.5 dpc embryos possess an allantois and amnion, but lack somites. A, allantois; Am, amnion; S, somite. Bars in A-G = 100 μm.