Figure 3
From: Optic cup and facial patterning defects in ocular ectoderm β-catenin gain-of-function mice
Gross morphology of Lens-cre ; Catnblox(ex3)mutant mice. (A) Dorsal view of the head and ventral view of the mouth (C) from an adult wild-type mouse. (B) Dorsal view of the head and ventral view of the mouth (D) of an adult Lens-cre; Catnblox(ex3) mutant mouse. (E, F) Ventral view of the anterior palate in X-gal stained control (E) and Topgal; Lens-cre; Catnblox(ex3) (F) E14.5 embryos. The dashed line in (E) indicates the midline. The arrowheads in (F) show the edge of the cleft in the palate of experimental embryos. (G, H) Unstained whole mount E15.5 normal embryo (G) and Lens-cre; Catnblox(ex3) mutant embryo (H). Hematoxylin and eosin stained eye region coronal paraffin section from a control embryo (I) and Lens-cre; Catnblox(ex3) mutant embryo (J) at E15.5. (K) Nile blue staining of whole mount P2 head from control mouse and (L) from Lens-cre;Catnblox(ex3) mutant mouse. el-eyelids, c-cornea, l-lens, r-retina, rpe-retinal pigmented epithelium, lg-lacrimal gland, ose-ocular surface ectoderm.