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Table 2 Comparison of cystic fibrosis disease phenotypes between human and animal models

From: Pathophysiologic consequences following inhibition of a CFTR-dependent developmental cascade in the lung

HUMAN DISEASE PHENOTYPE CFTR KNOCKOUT MOUSE MODEL PHENOTYPE TIUKO CF RAT PHENOTYPE
LUNG FIBROSIS FIBROSIS AND INFLAMMATION PRESENT BY 100 DAYS OF AGE
MRP8/14 ELEVATED DETECTED IN G551D MOUSE INCREASED PRENATALLY
AIRWAY REACTIVITY NOT DETECTED INCREASED WITH AGE
CHRONIC INFLAMMATION DETECTED IN CONGENIC MICE PRESENT BY 100 DAYS OF AGE