TY - JOUR AU - Grohmann, Maik AU - Spada, Fabio AU - Schermelleh, Lothar AU - Alenina, Natalia AU - Bader, Michael AU - Cardoso, M. Cristina AU - Leonhardt, Heinrich PY - 2005 DA - 2005/08/24 TI - Restricted mobility of Dnmt1 in preimplantation embryos: implications for epigenetic reprogramming JO - BMC Developmental Biology SP - 18 VL - 5 IS - 1 AB - Mouse preimplantation development is characterized by both active and passive genomic demethylation. A short isoform of the prevalent maintenance DNA methyltransferase (Dnmt1S) is found in the cytoplasm of preimplantation embryos and transiently enters the nucleus only at the 8-cell stage. SN - 1471-213X UR - https://doi.org/10.1186/1471-213X-5-18 DO - 10.1186/1471-213X-5-18 ID - Grohmann2005 ER -