TY - JOUR AU - Woda, Juliana M. AU - Calzonetti, Teresa AU - Hilditch-Maguire, Paige AU - Duyao, Mabel P. AU - Conlon, Ronald A. AU - MacDonald, Marcy E. PY - 2005 DA - 2005/08/18 TI - Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo JO - BMC Developmental Biology SP - 17 VL - 5 IS - 1 AB - Huntingtin, the HD gene encoded protein mutated by polyglutamine expansion in Huntington's disease, is required in extraembryonic tissues for proper gastrulation, implicating its activities in nutrition or patterning of the developing embryo. To test these possibilities, we have used whole mount in situ hybridization to examine embryonic patterning and morphogenesis in homozygous Hdhex4/5huntingtin deficient embryos. SN - 1471-213X UR - https://doi.org/10.1186/1471-213X-5-17 DO - 10.1186/1471-213X-5-17 ID - Woda2005 ER -